Sunday, May 10, 2020

Effectiveness of peer-led intervention for adolescents: A meta analysis of smoking prevention program

Abstract

Peer-led intervention is one of the beneficial approaches for preventing adolescents from health risk behavior. So, peer-led intervention may help to prevent adolescents from smoking cigarettes but impact of such intervention has not been studied well. Therefore, this study was conducted  to investigate the effect of peer-led intervention to prevent adolescents from smoking behavior. Pub MED, PschyINFO, EMBASE, Google scholar and Cochrane Library were searched from march to June, 2016 with set criteria in review protocol and only randomized control trials were included. Screening and data extraction were conducted and data from eligible studies were pooled. Number of studies included after full text review was three. Three eligible studies' data were extracted and further analyzed for risk of bias in Revman 5. Three studies targeting smoking behavior was pooled which represent 25,864 adolescents. Meta analysis  revealed  that odd ratio of smoking were lower in those receiving peer-led intervention compared to with not receiving peer-led intervention. Peer-led intervention may be effective in prevention of cigarette smoking among adolescents therefore it can play significant role in prevention of smoking behavior.
Keywords: Peer-led, smoking, behavior, adolescents, intervention

Introduction

              Smoking is one of the major health risk behaviors in adolescents. According to the World Health Organization (WHO, 2016) the prevalence of tobacco use among adolescents aged 13-15 years is: 8.3% (female) and 18.2%(male) globally, 7.2(female) and 21(male) in South East Asia, 13.8(female) and 17(male) in United States. At the same time, 80 percent of more than 1 billion smokers worldwide live in low and middle income countries where the burden of tobacco related illness and death is heaviest (WHO, 2016). Smoking is one of the leading causes of morbidity and mortality (US Department of Health and Human Services, 2014). In adolescents, smoking causes asthma and other respiratory diseases, and is well known as a risk factor for lung cancer in later life (The Cancer Council, 2016) . Both the government commitment and public awareness interventions have shown promise in preventing smoking in adolescents worldwide.
            Over 1.3 billion people, or 18% of the world's population, are protected by comprehensive national smoke-free laws (WHO, 2016). Despite efforts in smoking prevention, smoking behavior in adolescents has been increasing and it is considered as one of the major threats for adolescent health. According to the WHO, in Nepal, the prevalence of tobacco use among adolescents aged 13-15 years are; 5.3(female) and 13(male) was increased to 16.4(female) and 24.6(male) in 2011. Altogether 90 percent of smokers have started smoking by the age of 18 and 99 percent have started by the age of 26 (US department of health and human services, 2016). This indicates the importance of smoking prevention programs or interventions during adolescence. Peers are major social agents who influence the adolescents' behavior. They have similar values, ages, status and behaviors, and can share information and teach each other. So, peer-led interventions are considered as one of the major intervention strategies to reduce the health risk behavior among adolescents worldwide.
            Peers have great influence on positive and negative behavior of the adolescents. In peer-led interventions, peer education is used to influence peers in a positive way to improve health risk behavior(Raji, Abubakar, Oche, Kaoje, & Isah, 2014). Peer educators are generally of similar or slightly older age than the students receiving educational program(Mellanby, Newcombe, Rees, & Tripp, 2001). Peer educators are more likely to influence peers because they are usually less judgmental and credible to their peers and such intervention involving peers can access the hidden populations (Ye, et al., 2014). In most of the interventions, peer educators may act as a role model, innovator, and educator to change the health risk behavior of adolescents and solve health problems in partnership. The peer-led approach is quite popular in major health interventions related to HIV and AIDS, family planning and drug prevention. Peer education program in HIV prevention in low and middle income countries demonstrated that some success in changing community attitudes and norms but effects on other sexual behaviors and STI rates were equivocal (Tyndale & Barnett, 2010). Both peer-led and adult-led interventions are generally have their own place in effective sex education but the main challenge is which area should be dealt with peer-led intervention to get maximum benefit. Peer-led education is less effective in communicating factual information in one hand but in other hand it is more effective in dealing with teenage relationship and setting conservative norms(Mellanby et al., 2001). Peer-led interventions need more time to train peer and need more effort to fix the venue for peer education(Macarthur, Sean, Deborah, Matthew, & Rona, 2016).
              There are a number of types of peer-led interventions to prevent adolescents from smoking behavior. Each of these peer-led interventions uses different theory and principles. So, in this context, it is important to provide best possible evidences on peer-led interventions out of many interventions applied in smoking prevention programs worldwide. In this meta analysis, peer-led intervention means all the smoking prevention interventions which involved peers to delivery of smoking prevention activities directly or indirectly to adolescents.
            Till date, most of the systematic reviews were done on teacher-led school based programs and only very few systematic review were conducted on peer-led interventions. Most of the peer-led reviews were conducted to find the effect of peer-led interventions on multiple risk behaviors including alcohol, drug besides smoking behavior.  The main objective of this study is to assess the effectiveness of peer-led interventions for preventing adolescents (aged 13-19) from smoking. So, the set hypothesis for this study was peer-led interventions are more effective in preventing adolescents from smoking.

Methods

            The protocol of systematic review is prepared on the basis of question provided by the university. Then, it was sent to university professor for approval. After getting on approval on protocol from the university, review started. The primary objective of the review was to identify and review the effect of peer-led intervention in preventing adolescents aged 10-19 years from smoking behavior. This age group was chosen based on the WHO definition of adolescents and because many young people start smoking behavior below the age of 20.

Criteria for Considering Studies  

              The review included only randomized control trials (RCTs). Only articles published after 2005 were included. Moreover, papers published in non-English language and grey literature were also excluded. Only published journal papers were included in the study. The studies were considered on the basis of population, intervention, comparison, outcomes and context(PICOC).
Population(P). All the studies that included young people aged between 10-19 who were currently studying in school/college were included but out of school or college adolescents were not included in this meta analysis.
Intervention(I). Peer-led intervention means all the smoking prevention interventions which involved peers in the delivery of smoking prevention activities directly or indirectly to adolescents.
Comparison(C) : The studies assessed the effectiveness of the interventions on the basis of comparison between intervention and control group. The comparison was done on the basis of program intervention such as peer-led discussion and interaction program after peer-led intervention such as peer-led video show, lecture, poster, pamphlets, advocacy. Interventions with less than 6 months follow up period were excluded in selection process.
Outcomes(O). The primary outcome was smoking prevalence, which was measured as the number of new smokers and/or number of quitters. Only studies that had at least 6 months follow up period were considered.
Context(C).  Study included only peer-led interventions and it excluded multi-component interventions where one of the components was peer-led intervention.

Search Methods for Identification of Studies  

            A systematic literature search was performed to identify published randomized control trials(RCTs). Keywords and synonyms were identified through Google scholar and Pub Med limited search. The keywords and synonyms identified were used in extensive literature search in respective database. The basic search was done with major key words "adolescent", "Peer*", "smoking"," tobacco", "prevent*", “intervention".
            The search was done systematically by using four electronic databases namely "Pub Med", "PsycINFO ","EMBASE" and "Cochrane library". Furthermore, search was also carried out through search engine "Google scholar". Boolean operators were used during searching process. Search process was presented in PRISMA's recommended flow chart (Stovold, Beecher, Foxiee, & Noel-Storr, 2014). Duplicates were removed from total identified articles from above mentioned database and search engine step by step.
            Identified titles were reviewed and relevant articles were selected for further screening or abstract review. Screening of abstract was done based on predefined inclusion and exclusion criteria. After reviewing abstract, full articles from relevant studies were retrieved. Critical appraisal of full text articles was carried out among the selected articles in abstract review. Reasons for exclusion of full text articles were presented in flow chart in each step. Articles which met the inclusion criteria were retained for full analysis. The reference lists of selected articles further were searched for more relevant articles. Any confusion while selecting articles was resolved by discussion with study mentor of this meta analysis.
Figure 1
Preferred Reporting Items for Systematic Reviews PRISMA Flow diagram

Record identified through database searching (n=4036):
Cochrane library (n=69)
Pub Med(n=39)
PschyINFO(n=566)
EMBASE(n=412)
Google Scholar(n=2950)




Result after title screening
n=618


Result after abstract screening
n=577


Result after duplicate and non English  screening for full text review 
n=13



Full text article excluded (n=6)
1. Only protocol available(n=1)
2. Study under same sample (n=2)
3.Not specific and data was not enough for systematic review(n=1)
4. Contents was not specific to peer-led intervention(n=1)
5. Content was more specific to cost effectiveness (n=1)


Studies included in quantitative analysis
n=6


Studies selected in quantitative analysis
n=3


2 studies selected for meta analysis (Lotrean et al., 2010) &(Campbell et al., 2008)

Three multi -components studies were removed

Study which used "linear rate of change" removed after communication with researchers who were unable to give primary data i.e. number or percentage of new smoker in control and experimental group (Perry et al., 2009)
 Data Extraction and Analysis  

            Data were extracted by using Review Manager 5.3(RevMan) for each included study. Data were extracted for all included studies on study design, age of participants, gender of participants, intervention duration and follow up, brief overview of peer-led intervention and details of control group as in table 1. Data were extracted for never smoker. Both base line and follow up data were collected for both intervention and control groups. Confusion were solved by discussion with study mentor.
Table 1
Table of included studies
           
Studies at step II of selection process
Author
(Lotrean et al., 2010)
(Campbell et al., 2008)
(Perry et al., 2009)
Location
Romania
United Kingdom & Wales
India

Sample size

1071 students

10730 students

14063

Age of participants

13-14

12-13

6th and 8th graders

Behavior

Smoking

Smoking

Tobacco smoking & chewing

Setting

school

School

School

Interventions

School based smoking prevention program with video and peer-led discussion

A stop smoking in school trial program, peer supporters during informal interaction outside classroom encourage their  peers not to smoke

Peer-led classroom activities along with Peer-led activism, poster hanging and post cards to parents

Theoretical model


Intervention modality






Peer selection modality








Research design



Duration of intervention

Follow up

Social cognitive theory, Integrated model of change, social influence approach

5weekly video sessions of 45 minutes each. The program consist of theme introduction in class on video, activities, peer-led small groups discussion, home activities



Selection procedure for peer leaders was not mentioned clearly but teacher coordinated the lessons, assisted peer leaders and stimulate the students to participate. Both teachers and peer leaders have one hour information session before the beginning of the activities on content and characteristics of the program

Non-equivalent control group pretest-posttest quasi-experimental research design


5 weeks

9 months

Diffusion of innovation



10 week intervention during which peer supporters undertook informal conversation about smoking with their peers when travelling to and from school, in breaks, at lunch time and after school  in their free time and logged the conversation in diary

Recruitment meeting held with peer nominees to explain the role of peer supporter, question answer and obtain agreement  to attend the training course. Two days training course held out of school, facilitated by team of external trainer which aimed to provide short term risk to young people of smoking behavior


Equivalent time sample quasi-experimental research design



10 weeks


1,2 & 3 years period

Social cognitive theory



7 peer-led classroom activities as the main intervention for 6th and 8th graders. Besides this peer led activism outside classroom and posters were hung and post cards were sent to parents



No clear pear leader selection procedure mentioned. Sets of manuals were provided to teachers and peer leaders






Equivalent time sample quasi experimental research design



Approximately 4 months of each school year


1and 2 year period

Findings

A post test results indicated weekly smoking on set was 4.5 percent in experimental group verses 9.5 percent in control group. More than double new smoker in control group than in experimental group

The odds ratio of being a smoker in intervention compared with control school was 0.75(95% CI, 0.55-1.01) immediately after intervention(n=9349 students), 0.77(0.59-0.99) at one year follow up(n=9147 students) and 0.85(0.72-1.01) at two year follow up(n= 8756 students)
Intervention was fruitful in  reducing smoking prevalence in adolescents

Cigarette smoking linear rate of change was 1.37(95% CI, 0.72-2.02) in control group and 0.46(95% CI, -0.19-1.11) in intervention group
More students in control group smoked cigarette &bidis than students in the intervention group


Results

              Figure 1 shows the total number of studies identified, screened and reviewed. It shows the reason of exclusion of each excluded study after review of full articles. A total of 4036 articles were identified by database search and through Google scholar. The total number of articles after title screening  was 618 which further screened by abstract review. Altogether 577 articles were identified for abstract review. After removal of duplicate and non English articles  in abstract review process the total of 34 articles were selected. From 34 articles, finally 12 articles were selected for full text review. Six articles were selected after full text review of 12 articles. At this stage articles were excluded mainly due to the following reasons: Only protocol available, study were conducted in same sample, not enough data was available for systematic review, contents was not specific to peer-led interventions and contents was more specific to cost effectiveness. After further full review of six articles, three multi component studies were excluded. Finally, three studies were selected for quantitative analysis. Out of three articles two studies used the number of smokers as measurement units but one study used linear rate of change to calculate intervention effect. Authors of this articles were contacted for primary data to calculate odd ratio. Authors were unable to provide primary data of this study. Finally, two studies were selected for meta analysis.
            Table 1 summarizes the characteristics of the included studies. Selected three studies were conducted in Romania, UK & Wales and India. Out of three studies the first study included adolescents aged between  13-14,  while second study included student aged between 12-13 and third study included students  from grade 6 and 8 without mentioning their age. All included studies were targeted to tobacco smoking. Included studies were school based intervention which didn't cover out of school adolescents. All the studies were heterogeneous in nature where duration of intervention varied from one year to three years. Follow up period for all three studies were nine months to three years. Meta analysis of the studies’ outcomes from nine months to twelve months was conducted.
             A post test results indicated weekly smoking on set was 4.5 in experimental group verses 9.5 percent in control group in first study. More than double new smoker in control group than in experimental group. The first included study showed that  more than double new smoker in control group than in experimental group(Lotrean et al., 2010).
            In second study, the odd ratio of being a smoker in intervention compared with control school was 0.75(95% CI, 0.55-1.01) immediately after intervention (n=9349 students), 0.77(0.59-0.99) at one year follow up(n=9147 students) and 0.85(0.72-1.01) at two year follow up(n= 8756 students). Therefore, the study showed that intervention was fruitful in reducing smoking prevalence in adolescents in experiment group (Campbell et al., 2008).
            In third study, Cigarette smoking linear rate of change was 1.37(95% CI, 0.72-2.02) in control group and 0.46 (95% CI, -0.19-1.11) in intervention group More students in control group smoked cigarette & bidis than students in the intervention group. The study showed that more students in control group smoked cigarette and bidis than students in intervention group(Perry et al., 2009).

Forest Plot showing results for effectiveness of smoking prevention program in experimental and control group
              Figure 3 shows the effectiveness of peer led interventions by showing number of new smokers in follow up period in experimental and control group. Data were pooled for two main studies. In first study AR1(Lotrean et al., 2010)number of new smokers is higher in control group than experimental group with odd ratio 0.46(0.28,0.76) at 95% CI in fixed effect model. Similarly, in second study AR2(Campbell et al., 2008) number of new smokers is lower in experimental group with odds ratio 0.84(0.73,0.97) at 95% CI in fixed effect model. Though the sample size of the AR1 was small, the study demonstrates a significant effect favoring the intervention, which is greater than for AR2. The diamond of the forest plot shows that, overall, peer led intervention is an effective approach in smoking prevention for adolescents. The total effect shows odd ratio of 0.80(0.70-0.92) at 95% CI. As the overall odds ratio is less than 1, this indicates that such an intervention is effective in preventing adolescents to initiate smoking. Among the two studies, , I2=81%, chi2=5.20 df=1(p=0.02) which shows high statistical heterogeneity.

Discussion

Critical Appraisal

            Risk of bias was assessed using the Cochrane tool (Higgins & Greens, 2011). Cochrane tool was used to check the low, high and unclear risk of bias. The major risk of bias considered in the reviews were selection bias(Random sequence generation and allocation concealment), performance bias(blinding of participants and personnel), detection bias(blinding of outcome assessment), attrition bias(Incomplete outcome data), reporting bias(selective reporting) and other biases. Risk of bias analysis was done for three studies namely study 1 (Lotrean, Dijk, Mesters, Ionut, & De Vries, 2010), Study 2(Campbell et al., 2008) and study 3 (Perry, Stigler, Arora, & Reddy, 2009) shown in figure 2.
Figure 2
 Review author judgments about each risk of bias item presented as percentages across all included studies.

Selection Bias

            Random sequence generation. Altogether 10 schools randomly assigned and by tossing coins, the two groups randomly assigned as experimental and control group so there is low risk of selection bias due to random sequence generation in study 1(Lotrean et al., 2010). Study 2(Campbell et al., 2008) also showed low risk of selection bias as in this study stratified block randomization was done.
Study 3 (Perry, Stigler, Arora, & Reddy, 2009) showed unclear random sequence generation process but it highlighted about group randomized trial." As a means of ensuring representativeness, schools within each city were matched according to type of school and then randomly assigned to receive the tobacco use intervention program". The article did not mention the clear procedure of randomization.
Allocation concealment.  In study 1 (Lotrean et al., 2010), participants and Investigators could not foresee the assignment because all the names were kept in box and the investigator took the number by lottery and two created groups were named control and experiment group by tossing coin so there is low risk of selection bias due to allocation concealment. Actual blinding was not possible in this study. The study 2(Campbell et al., 2008) stated that the schools were allocated using randomly ordered list of schools for each stratum. It had low risk of selection bias due allocation concealment. For conceal allocation, another investigator was at different location and was unaware of school was next to randomize and random number generator was used to establish the group allocation of next school, which communicate to first investigator by telephone. in study 3(Perry et al., 2009)  stated that " Student response by the use of unique identification tag that was not recognizable to students or school staff over time so allocation concealment was probably done and therefore had low risk of selection bias.

Performance Bias

            If the participants were asked their view whether they stop smoking in future, many of them might say yes during self administered data collection, this might not be due to intervention effect but due to the participants knowledge about the intervention intention so there was high risk of performance bias due to lack of blinding of participants and personnel in study 1(Lotrean et al., 2010). As in previous study, Study 2 (Campbell et al., 2008) also showed actual blinding of participants and personnel was not possible in this study so it has high risk of performance bias. If the participants were asked their view regarding whether they stop smoking in future as the intervention itself named as "A stop smoking in school trial". Many of them might say yes during self administered data collection, this might not be due to intervention effect but due to the participants prior knowledge about the intervention intention.
            Study 3 (Perry et al., 2009) showed high risk of performance bias. Students, peers and teachers were aware about program intention so, in self administered questions when ask about their intention and prevalence they will answer as they wanted to stop smoking so, blinding of participants and personnel in this case was not be possible. No bio chemical analysis of tobacco use was done due to expense of obtaining and analyzing such data.
Detection bias
            Study 1(Lotrean et al., 2010)showed high risk of detection bias as blinding of outcomes assessment was not possible. Double blinding was not possible as the peer educators and trainer were trained and got manual. Students expressed their view in self administered questionnaire. So, participants might had knowledge about intervention intention students subconsciously answered questions according to program intention.  They had prior knowledge of  getting educational intervention.
            Study 2 (Campbell et al., 2008) had low risk of detection bias due to blinding of outcome assessment. "Comparison of self reported data and concentration of salivary cotinine shows 1% of students who reported not smoking had salivary cotinine concentration greater than 15ng/ml at 1 year follow up" this indicate the study not only collected outcome assessment through self administered questionnaire where probability of answering on the basis intervention intention was reduced by cross validation with saliva test.
            Study 3(Perry et al., 2009) did not mention about double blinding. Double blinding was not possible as the peer educators and supervisor teachers were trained and got standardized protocol on how to educate students. Students were expressed their view in self administered questionnaire during baseline, midline and end line. So, participants had knowledge about intervention intention so students generally subconsciously answered according to program intention. Blinding of outcome assessment might not possible. So, this study had high risk of detection bias.
Attrition Bias
            Study 1(Lotrean et al., 2010) had low risk of attrition bias due to complete outcome data. " Dropout rates were similar(p>0.05) in both condition, 11 % in experiment group and 9.8% in control group" which was mostly by absenteeism and change of schools by some students.  Similarly, study 2 (Campbell et al., 2008) also showed low risk of attrition bias." Two schools withdrew after randomization, one from the control group and one from the intervention group because of changes in decision by school management and replacement was done by each school one from each strata in the list" In 1 year follow up 93% students in control group and 96% student in intervention group participated; In 2 year follow up 90% students in control group and 94% students in intervention group participated which showed the dropout percentage seems not so high. Study 3(Perry et al., 2009) showed high risk of attrition bias. Follow up data from 2 of Delhi schools(1- intervention, 1- control school) was not obtained due to time constraint at these school. Three additional school in Delhi( 2 control and one intervention school) would not allow their 10th grader to be surveyed because of ensuing exams
Reporting Bias
            Study 1(Lotrean et al., 2010) had unclear risk of reporting bias. It measured behavioral outcomes and the secondary outcomes like attitudes, social influence, self efficacy and intention to smoke in future but study 2 (Campbell et al., 2008) showed low risk of reporting bias due to selective reporting. It  reported that outcomes as expected in four major time periods in baseline, immediately after intervention, at one year follow up and at two year follow up and measured outcome data were reported as planned. Study 3(Perry et al., 2009) reported outcome data of three major  period i.e. before the beginning of intervention, midpoint of intervention and after the completion of intervention so it had low risk of  reporting bias.
            Peer-led intervention generally pillars on two major theories: social cognitive and diffusion of innovation theory. Individual behavior is the result of interaction among cognition, behavior, environment and physiology. Learning by observing peers behavior and lifestyles which may lead to the particular behavior which become more pronounce when it is also goal directed. Adopted behavior eventually becomes self regulated behavior and its persistence depends on reinforcement and punishment for that particular behavior. The intervention generally use the process through which new ideas and products for enhancing particular behavior known and make available for young people leads to diffusion in the society.
            In this study, the impact of peer-led intervention on smoking behavior is quantified. The findings of the study showed that peer-led intervention can play a significant role in prevention of smoking behavior among adolescents. The pooling of two main studies including 11801 adolescents aged 12-14 adolescents suggests that  number of new smoker in experimental or intervention group was less in comparison to number of smoker in control or the without intervention group. The odds of becoming a new smoker were lower among those who received a peer-led intervention compared to control group( OR=0.80, 95% CI=0.70-0.92). This result is only based on two studies, as a third study that was relevant reported data using a different method. Importantly, the results of the third study are in broad agreement with the meta-analysis, further strengthening the findings of this systematic review.
            The systematic review of the studies suggested that peer-led interventions may be effective in preventing smoking behavior among adolescents but the evidence base is limited because of the high heterogeneity in included studies. Similarly, one of the systematic review on effectiveness of peer-led interventions to prevent tobacco, alcohol and/or drug use among young people aged 11-21 years also highlighted that most of the included studies on peer-led intervention were of low quality small studies which limited the evidence base of review(Macarthur et al., 2016).
            Out of three studies, two studies were based on equivalent time series quasi experimental design where selection of control and experimental group was done randomly only within group and pre-post test was done before the experiment and at different time intervals. One study was based on non-equivalent pre-post test quasi experimental design where selection of control and experimental and control group was done randomly within group but both groups were not tested for equivalency by any scientific method.

Limitation of Study

            The major limitation of this study was heterogeneity of the data due to differences in effect size, intervention modality and follow up period. In this review, the process of  peer-led intervention implementation was very different, one of the studies conducted used formal school setting for the intervention while other used informal out of class informal interaction for peer-led interventions which increased the heterogeneity among included studies. The scope of analysis was limited by exclusion of one of the major studies with sample size of 14063 because the authors of the study were unable to provide data on number of new smoker in intervention and control group. The authors used linear rate of change and base line data for control and intervention group(Perry et al., 2009) which was not compatible with data of other two studies but the result of third study also showed effectiveness of peer-led intervention in prevention of smoking behavior among adolescents. Therefore, this study was included in systematic review process and it was not included in meta analysis due to lack of primary data for the analysis during forest plot analysis.
            Furthermore, the study was limited due to exclusion of many studies due to their multi components nature where the peer-led intervention was one of the components besides other components. The study was conducted by single author as course assignment. The risk of bias might be higher in this study in comparison to other studies in which screening, critical appraisal and data extraction is done in duplicate. However, inclusion of studies was carried out by getting consensus from the mentor of this study.

Conclusion and Implication

          The findings shows peer-led intervention can play a significant  role in prevention of smoking behavior among adolescents based on social cognition and diffusion of innovation theory. Adolescents knowledge acquisition is directly related to observing peers' behavior and sharing experiences with peers during school and out of school time. Therefore, the interventions which involves peers can lead to positive health behavior than adult-led interventions because adolescents usually feel more comfortable with peers than with adult like teachers, parents, social workers. Moreover, innovations in peer-led interventions can lead to seek more information which eventually result in decision, information and confirmation to adopt new desired behavior.
          Only a few systematic reviews have been conducted in the past on the effectiveness of peer-led interventions as part of a multi-component intervention in relation to risk behavior in adolescents, but none have examined the effectiveness of peer-led interventions on their own for smoking in adolescents. This study has found that peer-led interventions are effective in preventing smoking behavior among adolescents, however, the scope of this study is limited by its total small sample size and high heterogeneity among included studies. Therefore, to draw the conclusion on effectiveness of peer-led  interventions on smoking behavior of adolescent, more robust and rigorous randomized control trials in wide range of geography and adolescents population was needed. Moreover, the more homogenous studies and large number of such studies can add more value to draw the conclusion on effectiveness of the peer-led intervention in reducing risk behavior among adolescents. Therefore, future randomized control trials with homogenous program modality can help to inform future peer-led interventions strategy and program implementation in reducing risk behavior among adolescents.




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" फेसबुके माया " (2020)

              गाउँमा असी वर्षका बुबा , विदेशबाट छोराको फोन आउने आशामा बसेका छन । आज बुबाको जन्मदिन । छोरा बुहारीलाई नि सम्...